Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers.

ABSTRACT: The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits at the molecular and/or cellular level, to predict the development of frailty, or even more interestingly, to improve health trajectories in older adults. Frailty reflects a state of increased vulnerability to stressors as a result of decreased physiologic reserves, and even dysregulation of multiple physiologic systems leading to adverse health outcomes for individuals of the same

SUBMITTER: Garcia-Gimenez JL 

PROVIDER: S-EPMC7919465 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature