Structure-Based Identification of Natural Products as SARS-CoV-2 M^pro Antagonist from Echinacea angustifolia Using Computational Approaches.

ABSTRACT: Coronavirus disease-19 (COVID-19) pandemic, caused by the novel SARS-CoV-2 virus, continues to be a global threat. The number of cases and deaths will remain escalating due to the lack of effective therapeutic agents. Several studies have established the importance of the viral main protease (M^pro) in the replication of SARS-CoV-2 which makes it an attractive target for antiviral drug development, including pharmaceutical repurposing and other medicinal chemistry approaches. Identification of natural products with considerable inhibitory potential against SARS-CoV-2 could be beneficial as a rapid and potent alternative with drug-likeness by comparison to de novo antiviral drug discovery approaches. Thereof, we carried out the structure-based screening of natural products from

SUBMITTER: Bharadwaj S 

PROVIDER: S-EPMC7919488 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature