Histone Modifying Enzymes in Gynaecological Cancers.

ABSTRACT: Genetic and epigenetic factors contribute to the development of cancer. Epigenetic dysregulation is common in gynaecological cancers and includes altered methylation at CpG islands in gene promoter regions, global demethylation that leads to genome instability and histone modifications. Histones are a major determinant of chromosomal conformation and stability, and unlike DNA methylation, which is generally associated with gene silencing, are amenable to post-translational modifications that induce facultative chromatin regions, or condensed transcriptionally silent regions that decondense resulting in global alteration of gene expression. In comparison, other components, crucial to the manipulation of chromatin dynamics, such as histone modifying enzymes, are not as well-studied. Inhibito

SUBMITTER: Ramarao-Milne P 

PROVIDER: S-EPMC7919659 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature