Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking.

ABSTRACT: The emergence of drug-resistant fungi has prompted an urgent threat alert from the US Centers for Disease Control (CDC). Biofilm assembly by these pathogens further impairs effective therapy. We recently identified an antifungal, turbinmicin, that inhibits the fungal vesicle-mediated trafficking pathway and demonstrates broad-spectrum activity against planktonically growing fungi. During biofilm growth, vesicles with unique features play a critical role in the delivery of biofilm extracellular matrix components. As these components are largely responsible for the drug resistance associated with biofilm growth, we explored the utility of turbinmicin in the biofilm setting. We found that turbinmicin disrupted extracellular vesicle (EV) delivery during biofilm growth and that this impaired th

SUBMITTER: Zhao M 

PROVIDER: S-EPMC7919718 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature