Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment.

ABSTRACT:

Background

Knowledge of immune cell phenotypes, function, and developmental trajectory in acute myeloid leukemia (AML) microenvironment is essential for understanding mechanisms of evading immune surveillance and immunotherapy response of targeting special microenvironment components.

Methods

Using a single-cell RNA sequencing (scRNA-seq) dataset, we analyzed the immune cell phenotypes, function, and developmental trajectory of bone marrow (BM) samples from 16 AML patients and 4 healthy donors, but not AML blasts.

Results

We observed a significant difference between normal and AML BM immune cells. Here, we defined the diversity of dendritic cells (DC) and macrophages in different AML patients. We also identified several unique immune cell types including T helper cell

SUBMITTER: Guo R 

PROVIDER: S-EPMC7919996 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature