Cardiovascular "Patterns" of H₂S and SSNO^--Mix Evaluated from 35 Rat Hemodynamic Parameters.

ABSTRACT: This work is based on the hypothesis that it is possible to characterize the cardiovascular system just from the detailed shape of the arterial pulse waveform (APW). Since H₂S, NO donor S-nitrosoglutathione (GSNO) and their H₂S/GSNO products (SSNO^--mix) have numerous biological actions, we aimed to compare their effects on APW and to find characteristic "patterns" of their actions. The right jugular vein of anesthetized rats was cannulated for i.v. administration of the compounds. The left carotid artery was cannulated to detect APW. From APW, 35 hemodynamic parameters (HPs) were evaluated. H₂S transiently influenced all 35 HPs and from their cross-relationships to systolic blood pressure "patterns" and direct/indirect signaling pathways of the H

SUBMITTER: Tomasova L 

PROVIDER: S-EPMC7920056 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature