Adaptive Therapy for Metastatic Melanoma: Predictions from Patient Calibrated Mathematical Models.

ABSTRACT: Adaptive therapy is an evolution-based treatment approach that aims to maintain tumor volume by employing minimum effective drug doses or timed drug holidays. For successful adaptive therapy outcomes, it is critical to find the optimal timing of treatment switch points in a patient-specific manner. Here we develop a combination of mathematical models that examine interactions between drug-sensitive and resistant cells to facilitate melanoma adaptive therapy dosing and switch time points. The first model assumes genetically fixed drug-sensitive and -resistant popul tions that compete for limited resources. The second model considers phenotypic switching between drug-sensitive and -resistant cells. We calibrated each model to fit melanoma patient biomarker changes over time and predicted pat

SUBMITTER: Kim E 

PROVIDER: S-EPMC7920057 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature