A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes.

ABSTRACT:

Background

A closed-loop system of insulin delivery (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes.

Methods

In a 16-week, multicenter, randomized, open-label, parallel-group trial, we assigned, in a 3:1 ratio, children 6 to 13 years of age who had type 1 diabetes to receive treatment with the use of either a closed-loop system of insulin delivery (closed-loop group) or a sensor-augmented insulin pump (control group). The primary outcome was the percentage of time that the glucose level was in the target range of 70 to 180 mg per deciliter, as measured by continuous glucose monitoring.

Results

A total of 101 children underwent randomization (78 to the closed-loop group and 23 to the control group); the glycated hemog

SUBMITTER: Breton MD 

PROVIDER: S-EPMC7920146 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature