Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinoma.

ABSTRACT:

Aims

Polymorphous adenocarcinoma (PAC) usually follows an indolent course, but some cases may show recurrences and high-grade features. The genetic events associated with recurrences and high-grade versions are yet to be defined. Our aim was to determine the genetic underpinning of recurrent PACs of the salivary gland and the repertoire of somatic genetic alterations in cases with high-grade histology.

Methods and results

Four PACs from three patients, including one case with matching primary and recurrent tumours, one de-novo high-grade PAC, and a PAC that transformed to a high-grade tumour following multiple recurrences, were subjected to targeted sequencing (Memorial Sloan Kettering Mutation Profiling of Actionable Cancer Targets assay) or whole-exome sequencing. Both mat

SUBMITTER: Sebastiao APM 

PROVIDER: S-EPMC7920221 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature