Drug-induced Parkinsonism: A strong predictor of idiopathic Parkinson's disease.

ABSTRACT:

Background

Although Idiopathic Parkinson's disease (IPD) develops in considerable patients with drug-induced Parkinsonism (DIP), the association hasn't been well defined. We aimed to evaluate the underlying association and risk factors of DIP and IPD.

Methods

A retrospective cohort study using National Health Insurance Claims data in 2011-2016 was conducted. New-onset DIP patients in 2012 were selected and matched with active controls having diabetes mellitus at a 1:4 ratio by age, sex, and Charlson's Comorbidity Index score. Comorbidity, causative drugs, and prescription days were evaluated as covariates.

Results

A total of 441 DIP were selected. During the 4-year follow up, 14 IPD events in the DM group but 62 events in the DIP group were observed (adjusted hazard r

SUBMITTER: Jeong S 

PROVIDER: S-EPMC7920346 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature