Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy.

ABSTRACT: Influenza virus infections are major public health threats due to their high rates of morbidity and mortality. Upon influenza virus entry, host cells experience modifications of endomembranes, including those used for virus trafficking and replication. Here we report that influenza virus infection modifies mitochondrial morphodynamics by promoting mitochondria elongation and altering endoplasmic reticulum-mitochondria tethering in host cells. Expression of the viral RNA recapitulates these modifications inside cells. Virus induced mitochondria hyper-elongation was promoted by fission associated protein DRP1 relocalization to the cytosol, enhancing a pro-fusion status. We show that altering mitochondrial hyper-fusion with Mito-C, a novel pro-fission compound, not only restores mitochondrial

SUBMITTER: Pila-Castellanos I 

PROVIDER: S-EPMC7920353 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature