The impact of statin use prior to intensive care unit admission on critically ill patients with sepsis.

ABSTRACT:

Objective

To evaluate the impact of pre-intensive care unit admission (pre-ICU) statin use on all-cause in-hospital mortality and ICU length of stay (LOS).

Design

Retrospective cohort study.

Setting

Adult ICUs at tertiary hospitals.

Patients

Adult critically ill patients diagnosed with sepsis admitted to the ICUs.

Intervention

The exposure was pre-ICU statin prescription (statin users); unexposed represented absence of pre-ICU prescription (non-users).

Measurement and main results

We used the 2001-2012 Medical Information Mart for Intensive Care-III (MIMIC-III) database to determine average treatment effect (ATE) of pre-ICU statin use on 30-day ICU mortality, ICU LOS, and 30-day in-hospital mortality using the Augmented Inverse Propensity Weighted

SUBMITTER: Chinaeke EE 

PROVIDER: S-EPMC7920641 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature