Development and Relevance of Hypercapnia in COPD.

ABSTRACT:

Background

Identification of patients who may become hypercapnic, or develop acidotic hypercapnic respiratory failure (AHRF), is important in chronic obstructive pulmonary disease (COPD) to avoid hospital admission and select patients for use of home NIV. This study aimed to identify factors associated with presence and development of hypercapnia.

Methods

1224 patients, 637 with COPD and 587 with alpha 1 antitrypsin deficiency (AATD), from 4 previously established patient cohorts, were included in cross-sectional analyses of hypercapnia (PaCO₂ ≥ 6.5 kPa or 48.8 mmHg), focusing on phenotypic features of COPD and mortality. Longitudinal associations of rising PaCO₂ were also assessed. A second cohort of 160 COPD patients underwent sleep studies and 1-year

SUBMITTER: Dave C 

PROVIDER: S-EPMC7920710 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature