The serum metabolome of COVID-19 patients is distinctive and predictive.

ABSTRACT:

Background

Metabolism is critical for sustaining life, immunity and infection, but its role in COVID-19 is not fully understood.

Methods

Seventy-nine COVID-19 patients, 78 healthy controls (HCs) and 30 COVID-19-like patients were recruited in a prospective cohort study. Samples were collected from COVID-19 patients with mild or severe symptoms on admission, patients who progressed from mild to severe symptoms, and patients who were followed from hospital admission to discharge. The metabolome was assayed using gas chromatography-mass spectrometry.

Results

Serum butyric acid, 2-hydroxybutyric acid, l-glutamic acid, l-phenylalanine, l-serine, l-lactic acid, and cholesterol were enriched in COVID-19 and COVID-19-like patients versus HCs. Notably, d-fructose and succinic

SUBMITTER: Shi D 

PROVIDER: S-EPMC7920809 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature