Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea.

ABSTRACT:

Background

Obstructive Sleep Apnea (OSA) is a highly prevalent and underdiagnosed sleep disorder. Recent studies suggest that OSA might disrupt the biological clock, potentially causing or worsening OSA-associated comorbidities. However, the effect of OSA treatment on clock disruption is not fully understood.

Methods

The impact of OSA and short- (four months) and long-term (two years) OSA treatment, with Continuous Positive Airway Pressure (CPAP), on the biological clock was investigated at four time points within 24 h, in OSA patients relative to controls subjects (no OSA) of the same sex and age group, in a case-control study. Plasma melatonin and cortisol, body temperature and the expression levels and rhythmicity of eleven clock genes in peripheral blood mononuclear cell

SUBMITTER: Gaspar LS 

PROVIDER: S-EPMC7920825 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature