A Gene Mutation Signature Predicting Immunotherapy Benefits in Patients With NSCLC.

ABSTRACT:

Introduction

Identification of patients who can benefit from immune checkpoint blockade (ICB) therapy is key for improved clinical outcome. Recently, U.S. Food and Drug Administration approved tumor mutational burden (TMB) high (TMB-H or TMB ≥ 10) as a biomarker for pembrolizumab treatment of solid tumors. We intend to test the hypothesis that mutations in select genes may be a better predictor of NSCLC response to ICB therapy than TMB-H.

Methods

We compiled a list of candidate genes that may predict for benefits from ICB treatment by use of data from a recently published cohort of 350 patients with NSCLC. We then evaluated the influences of different mutation signatures in the candidate genes on ICB efficacy. They were also compared with TMB-H. The predictive powers of diff

SUBMITTER: Pan D 

PROVIDER: S-EPMC7920921 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature