Determinants of attained estradiol levels in response to oral estradiol plus progesterone therapy.

ABSTRACT:

Objectives

Among postmenopausal women taking hormone therapy (HT), the estradiol (E2) dose and E2 levels were differentially associated with change in metabolic measures. We evaluated determinants of attained E2 levels in response to HT.

Methods

Postmenopausal women from the REPLENISH trial tested four formulations of oral combined E2 and progesterone compared with placebo. Mixed-effects linear models assessed characteristics associated with E2 levels among women with ≥80% HT compliance, adjusted for E2 dose and baseline E2 level.

Results

Among 1173 postmenopausal women with mean (standard deviation) age 55 (4.3) years and 5.2 (4.8) years since menopause, higher treated E2 levels were significantly related to younger age, more recent menopause, and current alcohol use

SUBMITTER: Sriprasert I 

PROVIDER: S-EPMC7920923 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature