A cis-regulatory change underlying the motor neuron-specific loss of Ebf expression in immotile tunicate larvae.

ABSTRACT: Many species in the tunicate family Molgulidae have independently lost their swimming larval form and instead develop as tailless, immotile larvae. These larvae do not develop structures that are essential for swimming such as the notochord, otolith, and tail muscles. However, little is known about neural development in these nonswimming larvae. Here, we studied the patterning of the Motor Ganglion (MG) of Molgula occulta, a nonswimming species. We found that spatial patterns of MG neuron regulators in this species are conserved, compared with species with swimming larvae, suggesting that the gene networks regulating their expression are intact despite the loss of swimming. However, expression of the key motor neuron regulatory gene Ebf (Collier/Olf/EBF) was reduced in the developing MG of

SUBMITTER: Lowe EK 

PROVIDER: S-EPMC7920938 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature