Minimal contribution of IP₃R2 in cardiac differentiation and derived ventricular-like myocytes from human embryonic stem cells.

ABSTRACT: Type 2 inositol 1,4,5-trisphosphate receptor (IP₃R2) regulates the intracellular Ca²⁺ release from endoplasmic reticulum in human embryonic stem cells (hESCs), cardiovascular progenitor cells (CVPCs), and mammalian cardiomyocytes. However, the role of IP₃R2 in human cardiac development is unknown and its function in mammalian cardiomyocytes is controversial. hESC-derived cardiomyocytes have unique merits in disease modeling, cell therapy, and drug screening. Therefore, understanding the role of IP₃R2 in the generation and function of human cardiomyocytes would be valuable for the application of hESC-derived cardiomyocytes. In the current study, we investigated the role of IP₃R2 in the differentiation of hESCs to cardiomyocytes and in t

SUBMITTER: Zhang P 

PROVIDER: S-EPMC7921119 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature