Interaction analyses based on growth parameters of GWAS between Escherichia coli and Staphylococcus aureus.

ABSTRACT: To accurately explore the interaction mechanism between Escherichia coli and Staphylococcus aureus, we designed an ecological experiment to monoculture and co-culture E. coli and S. aureus. We co-cultured 45 strains of E. coli and S. aureus, as well as each species individually to measure growth over 36 h. We implemented a genome wide association study (GWAS) based on growth parameters (λ, R, A and s) to identify significant single nucleotide polymorphisms (SNPs) of the bacteria. Three commonly used growth regression equations, Logistic, Gompertz, and Richards, were used to fit the bacteria growth data of each strain. Then each equation's Akaike's information criterion (AIC) value was calculated as a commonly used information criterion. We used the optimal growth equation to estimate the f

SUBMITTER: Liang Y 

PROVIDER: S-EPMC7921238 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature