Bacillus Calmette-Guerin (BCG): the adroit vaccine.

ABSTRACT:

Background

The Bacillus Calmette-Guerin (BCG) vaccine has been in use for 99 years, and is regarded as one of the oldest human vaccines known today. It is recommended primarily due to its effect in preventing the most severe forms of tuberculosis, including disseminated tuberculosis and meningeal tuberculosis in children; however, its efficacy in preventing pulmonary tuberculosis and TB reactivation in adults has been questioned. Several studies however have found that asides from its role in tuberculosis prevention, the BCG vaccine also has protective effects against a host of other viral infections in humans, an effect which has been termed: heterologous, non-specific or off-target.

Objectives

As we approach 100 years since the discovery of the BCG vaccine, we review the e

SUBMITTER: Adesanya OA 

PROVIDER: S-EPMC7921379 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature