Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.

ABSTRACT: Tau pathology in Alzheimer's disease (AD) spreads in a predictable pattern that corresponds with disease symptoms and severity. At post-mortem there are cortical regions that range from mildly to severely affected by tau pathology and neuronal loss. A comparison of the molecular signatures of these differentially affected areas within cases and between cases and controls may allow the temporal modelling of disease progression. Here we used RNA sequencing to explore differential gene expression in the mildly affected primary visual cortex and moderately affected precuneus of ten age-, gender- and RNA quality-matched post-mortem brains from AD patients and healthy controls. The two regions in AD cases had similar transcriptomic signatures but there were broader abnormalities in the precuneus

SUBMITTER: Guennewig B 

PROVIDER: S-EPMC7921390 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature