A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls.

ABSTRACT:

Background

A research priority in finding a cure for HIV is to establish methods to accurately locate and quantify where and how HIV persists in people living with HIV (PLWH) receiving suppressive antiretroviral therapy (ART). Infusing copper-64 (⁶⁴Cu) radiolabelled broadly neutralising antibodies targeting HIV envelope (Env) with CT scan and positron emission tomography (PET) identified HIV Env in tissues in SIV infected non-human primates . We aimed to determine if a similar approach was effective in people living with HIV (PLWH).

Methods

Unmodified 3BNC117 was compared with 3BNC117 bound to the chelator MeCOSar and ⁶⁴Cu (⁶⁴Cu-3BNC117) in vitro to assess binding and neutralization. In a clinical trial ⁶⁴Cu-3BNC117 was infused int

SUBMITTER: McMahon JH 

PROVIDER: S-EPMC7921458 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature