The histone replacement gene His4r is involved in heat stress induced chromatin rearrangement.

ABSTRACT: His4r is the only known variant of histone H4 in Drosophila. It is encoded by the His4r single-copy gene that is located outside of the histone gene cluster and expressed in a different pattern than H4, although the encoded polypeptides are identical. We generated a null mutant (His4r^Δ42) which is homozygous viable and fertile without any apparent morphological defects. Heterozygous His4r^Δ42 is a mild suppressor of position-effect variegation, suggesting that His4r has a role in the formation or maintenance of condensed chromatin. Under standard conditions loss of His4r has a modest effect on gene expression. Upon heat-stress the induction of the Heat shock protein (HSP) genes Hsp27 and Hsp68 is stronger in His4r^Δ42 mutants with concordantly increased survi

SUBMITTER: Farago A 

PROVIDER: S-EPMC7921661 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature