Dopaminergic and Metabolic Correlations With Cognitive Domains in Non-demented Parkinson's Disease.

ABSTRACT:

Background

Accruing positron emission tomography (PET) studies have suggested that dopaminergic functioning and metabolic changes are correlated with cognitive dysfunction in Parkinson's disease (PD). Yet, the relationship between dopaminergic or cerebral metabolism and different cognitive domains in PD is poorly understood. To address this scarcity, we aimed to investigate the interactions among dopaminergic bindings, metabolic network changes, and the cognitive domains in PD patients.

Methods

We recruited 41 PD patients, including PD patients with no cognitive impairment (PD-NC; n = 21) and those with mild cognitive impairment (PD-MCI; n = 20). All patients underwent clinical evaluations and a schedule of neuropsychological tests and underwent both 11C-N-2-ca

SUBMITTER: Han L 

PROVIDER: S-EPMC7921728 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature