Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood.

ABSTRACT: T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56⁺ and CD56^- subsets most of the NKG2C⁺ T cells had a phenotype of highly differentiated CD8⁺ TEMRA cells. The CD56⁺NKG2C⁺ T cells also expressed a number of NK cell receptors, such as NKG2D, CD16, KIR2DL2/DL3, and maturation marker CD57 more often than the CD56^-NKG2C⁺CD3⁺ cells. TCR β-chain repertoire of the CD3⁺CD56⁺NKG2C⁺ cell fraction was limited by the prevalence of one or several clonotypes which can be found within the most abundant clonotypes in total or CD8⁺

SUBMITTER: Kovalenko EI 

PROVIDER: S-EPMC7921799 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature