Electrochemical immunosensor with Cu₂O nanocube coating for detection of SARS-CoV-2 spike protein.

ABSTRACT: Severe acute respiratory syndrome SARS-CoV-2 has caused a global pandemic starting in 2020. Accordingly, testing is crucial for mitigating the economic and public health effects. In order to facilitate point-of-care diagnosis, this study aims at presenting a label-free electrochemical biosensor as a powerful nanobiodevice for SARS-CoV-2 spike protein detection. Utilizing the IgG anti-SARS-CoV-2 spike antibody onto the electrode surface as a specific platform in an ordered orientation through staphylococcal protein A (ProtA) is highly significant in fabricating the designed nanobiodevice. In this sense, the screen-printed carbon electrode modified with Cu₂O nanocubes (Cu₂O NCs), which provide a large surface area in a very small space, was applied in order to increase

SUBMITTER: Rahmati Z 

PROVIDER: S-EPMC7921825 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature