The OFD1 protein is a novel player in selective autophagy: another tile to the cilia/autophagy puzzle.

ABSTRACT: The autophagy-lysosomal pathway is one of the main degradative routes which cells use to balance sources of energy. A number of proteins orchestrate the formation of autophagosomes, membranous organelles instrumental in autophagy. Selective autophagy, involving the recognition and removal of specific targets, is mediated by autophagy receptors, which recognize cargos and the autophagosomal membrane protein LC3 for lysosomal degradation. Recently, bidirectional crosstalk has emerged between autophagy and primary cilia, microtubule-based sensory organelles extending from cells and anchored by the basal body, derived from the mother centriole of the centrosome. The molecular mechanisms underlying the direct role of autophagic proteins in cilia biology and, conversely, the impact of this organ

SUBMITTER: Morleo M 

PROVIDER: S-EPMC7921851 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature