Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis.

ABSTRACT:

Objective

Autophagy is a physiological self-eating process that can promote cell survival or activate cell death in eukaryotic cells. In skeletal muscle, it is important for maintaining muscle mass and function that is critical to sustain mobility and regulate metabolism. The UV radiation resistance-associated gene (UVRAG) regulates the early stages of autophagy and autophagosome maturation and plays a key role in endosomal trafficking. This study investigated the essential in vivo role of UVRAG in skeletal muscle biology.

Methods

To determine the role of UVRAG in skeletal muscle in vivo, we generated muscle-specific UVRAG knockout mice using the Cre-loxP system driven by Myf6 promoter that is exclusively expressed in skeletal muscle. Myf6-Cre⁺ UVRAG^fl/fl

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC7921879 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature