Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery.

ABSTRACT: Tumor-specific fluorescence labeling is promising for real-time visualization of solid malignancies during surgery. There are a number of technologies to confer tumor-specific fluorescence. Antibodies have traditionally been used due to their versatility in modifications; however, their large size hampers efficient fluorophore delivery. Nanobodies are a novel class of molecules, derived from camelid heavy-chain only antibodies, that have shown promise for tumor-specific fluorescence labeling. Nanobodies are ten times smaller than standard antibodies, while maintaining antigen-binding capacity and have advantageous features, including rapidity of tumor labeling, that are reviewed in the present report. The present report reviews special considerations needed in developing nanobody probes, t

SUBMITTER: Lwin TM 

PROVIDER: S-EPMC7921980 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature