Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus.

ABSTRACT: Despite an excellent track record, microbial drug discovery suffers from high rates of rediscovery. Better workflows for the rapid investigation of complex extracts are needed to increase throughput and to allow early prioritization of samples. In addition, systematic characterization of poorly explored strains is seldomly performed. Here, we report a metabolomic study of 72 isolates belonging to the rare actinomycete genus Planomonospora, using a workflow of commonly used open access tools to investigate its secondary metabolites. The results reveal a correlation of chemical diversity and strain phylogeny, with classes of metabolites exclusive to certain phylogroups. We were able to identify previously reported Planomonospora metabolites, including the ureylene-containing ol

SUBMITTER: Zdouc MM 

PROVIDER: S-EPMC7922807 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature