Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases.

ABSTRACT: The incidence of kidney disease is rising, constituting a significant burden on the healthcare system and making identification of new therapeutic targets increasingly urgent. The heme oxygenase (HO) system performs an important function in the regulation of oxidative stress and inflammation and, via these mechanisms, is thought to play a role in the prevention of non-specific injuries following acute renal failure or resulting from chronic kidney disease. The expression of HO-1 is strongly inducible by a wide range of stimuli in the kidney, consequent to the kidney's filtration role which means HO-1 is exposed to a wide range of endogenous and exogenous molecules, and it has been shown to be protective in a variety of nephropathological animal models. Interestingly, the positive effect of

SUBMITTER: Grunenwald A 

PROVIDER: S-EPMC7923026 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature