Use of hiPSC to explicate genomic predisposition to anthracycline-induced cardiotoxicity.
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SUBMITTER: Magdy T
PROVIDER: S-EPMC7923254 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Use of hiPSC to explicate genomic predisposition to anthracycline-induced cardiotoxicity.
Magdy Tarek T Burridge Paul W PW
Pharmacogenomics 20210115 1
The anticancer agents of the anthracycline family are commonly associated with the potential to cause severe toxicity to the heart. To solve the question of why particular a patient is predisposed to anthracycline-induced cardiotoxicity (AIC), researchers have conducted numerous pharmacogenomic studies and identified more than 60 loci associated with AIC. To date, none of these identified loci have been developed into US FDA-approved biomarkers for use in routine clinical practice. With advances ...[more]
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