The male germline-specific protein MAPS is indispensable for pachynema progression and fertility.

ABSTRACT: Meiosis is a specialized cell division that creates haploid germ cells from diploid progenitors. Through differential RNA expression analyses, we previously identified a number of mouse genes that were dramatically elevated in spermatocytes, relative to their very low expression in spermatogonia and somatic organs. Here, we investigated in detail 1700102P08Rik, one of these genes, and independently conclude that it encodes a male germline-specific protein, in agreement with a recent report. We demonstrated that it is essential for pachynema progression in spermatocytes and named it male pachynema-specific (MAPS) protein. Mice lacking Maps (Maps^-/- ) suffered from pachytene arrest and spermatocyte death, leading to male infertility, whereas female fert

SUBMITTER: Li M 

PROVIDER: S-EPMC7923350 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature