Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.

ABSTRACT:

Background

Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer's disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate disease biomarkers. While several biological changes that occur early in the disease development have already been recognized, the need for further characterization of the pathophysiological mechanisms behind AD still remains.

Methods

In this study, we investigated cerebrospinal fluid (CSF) levels of 104 proteins in 307 asymptomatic 70-year-olds from the H70 Gothenburg Birth Cohort Studies using a multiplexed antibody- and bead-based technology.

Results

The protein levels were first correlated with the core AD CSF biomarker

SUBMITTER: Remnestal J 

PROVIDER: S-EPMC7923505 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature