Blinatumomab-induced T cell activation at single cell transcriptome resolution.

ABSTRACT:

Background

Bi-specific T-cell engager (BiTE) antibody is a class of bispecific antibodies designed for cancer immunotherapy. Blinatumomab is the first approved BiTE to treat acute B cell lymphoblastic leukemia (B-ALL). It brings killer T and target B cells into close proximity, activating patient's autologous T cells to kill malignant B cells via mechanisms such as cytolytic immune synapse formation and inflammatory cytokine production. However, the activated T-cell subtypes and the target cell-dependent T cell responses induced by blinatumomab, as well as the mechanisms of resistance to blinatumomab therapy are largely unknown.

Results

In this study, we performed single-cell sequencing analysis to identify transcriptional changes in T cells following blinatumomab-induced T

SUBMITTER: Huo Y 

PROVIDER: S-EPMC7923532 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature