Astrocytes lure CXCR2-expressing CD4⁺ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic neurological disease of the central nervous system driven by peripheral immune cell infiltration and glial activation. The pathological hallmark of MS is demyelination, and mounting evidence suggests neuronal damage in gray matter is a major contributor to disease irreversibility. While T cells are found in both gray and white matter of MS tissue, they are typically confined to the white matter of the most commonly used mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Here, we used a modified EAE mouse model (Type-B EAE) that displays severe neuronal damage to investigate the interplay between peripheral immune cells and glial cells in the event of neuronal damage. We show that CD4⁺ T cells migrate to the spinal cord gray m

SUBMITTER: Khaw YM 

PROVIDER: S-EPMC7923593 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature