Emergence of diauxie as an optimal growth strategy under resource allocation constraints in cellular metabolism.

ABSTRACT: Diauxie, or the sequential consumption of carbohydrates in bacteria such as Escherichia coli, has been hypothesized to be an evolutionary strategy which allows the organism to maximize its instantaneous specific growth-giving the bacterium a competitive advantage. Currently, the computational techniques used in industrial biotechnology fall short of explaining the intracellular dynamics underlying diauxic behavior. In particular, the understanding of the proteome dynamics in diauxie can be improved. We developed a robust iterative dynamic method based on expression- and thermodynamically enabled flux models to simulate the kinetic evolution of carbohydrate consumption and cellular growth. With minimal modeling assumptions, we couple kinetic uptakes, gene expression, and metabolic ne

SUBMITTER: Salvy P 

PROVIDER: S-EPMC7923608 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature