Health Potential of Aloe vera against Oxidative Stress Induced Corneal Damage: An "In Vitro" Study.

ABSTRACT: Fuchs endothelial corneal dystrophy (FECD) is characterized by the gradual deterioration of corneal endothelial cells (CECs) and is the most common cause of corneal transplantation worldwide. CECs apoptosis caused by oxidative stress plays a pivotal role in the pathogenesis of FECD. Antioxidant compounds have been of considerable significance as a candidate treatment in the management of corneal diseases. Based on these findings, the objective of this study was to evaluate the effects of an aloe extract with antioxidant properties, in an "in vitro" model of FECD. Human corneal epithelial (HCE) cells were preincubated with aloe extract 100 μg/mL, two hours before hydrogen peroxide (H2O2) stimulus. H2O2 challenge significantly reduced the cell viability, increased the generation of Reactive

SUBMITTER: Ceravolo I 

PROVIDER: S-EPMC7923787 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature