Human perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine.

ABSTRACT:

Background

The optimisation of learning has long been a focus of scientific research, particularly in relation to improving psychological treatment and recovery of brain function. Previously, partial N-methyl-D-aspartate agonists have been shown to augment reward learning, procedural learning and psychological therapy, but many studies also report no impact of these compounds on the same processes.

Aims

Here we investigate whether administration of an N-methyl-D-aspartate partial agonist (D-cycloserine) modulates a previously unexplored process - tactile perceptual learning. Further, we use a longitudinal design to investigate whether N-methyl-D-aspartate-related learning effects vary with time, thereby providing a potentially simple explanation for apparent mixed effects in

SUBMITTER: Dempsey-Jones H 

PROVIDER: S-EPMC7924109 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature