Quaternary and quinary molecular solids based on structural inequivalence and combinatorial approaches: 2-nitro-resorcinol and 4,6-di-chloro-resorcinol.

ABSTRACT: A synthetic strategy for the formation of stoichiometric quaternary and non-stoichiometric quinary solids is outlined. A series of 2-nitro-resorcinol-based quaternary cocrystals were developed from binary precursors in two conceptual stages. In the first stage, ternary solids are synthesized based on the structural inequivalence at two recognition sites in the binary. In the second stage, the ternary is homologated into a stoichiometric quaternary based on the same concept. Any cocrystal without an inequivalence becomes a synthetic dead end. The combinatorial approach involves lower cocrystal systems with different structural environments and preferred synthon selection from a synthon library in solution. Such are the stepping stones for the isolation of higher cocrystals. In addition, a q

SUBMITTER: Rajkumar M 

PROVIDER: S-EPMC7924232 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature