The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.

ABSTRACT:

Rationale

Asthma is associated with chronic changes in the airway epithelium, a key target of SARS-CoV-2. Many epithelial changes are driven by the type 2 cytokine IL-13, but the effects of IL-13 on SARS-CoV-2 infection are unknown.

Objectives

We sought to discover how IL-13 and other cytokines affect expression of genes encoding SARS-CoV-2-associated host proteins in human bronchial epithelial cells (HBECs) and determine whether IL-13 stimulation alters susceptibility to SARS-CoV-2 infection.

Methods

We used bulk and single cell RNA-seq to identify cytokine-induced changes in SARS-CoV-2-associated gene expression in HBECs. We related these to gene expression changes in airway epithelium from individuals with mild-moderate asthma and chronic obstructive pulmonary dise

SUBMITTER: Bonser LR 

PROVIDER: S-EPMC7924269 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature