Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients.

ABSTRACT: The community structure and metabolic potential of gut microbiome is not well investigated, especially in chronically critically ill patients with prolonged dependence on support systems after severe brain disorders. Microbial phenolic metabolites can target the brain function by the direct and indirect modulation of inflammation. The aim of this study was to investigate the features of the gut microbiota and profile of certain metabolites in the progression and reversibility of neurological disorders in chronically critically ill patients. Fecal samples were collected in dynamics from such patients (n = 44) and analyzed using 16S rRNA sequencing. Serum microbial and mitochondrial metabolites were measured by GC-MS and compared with the biomarkers and clinical neurological scores. T

SUBMITTER: Chernevskaya E 

PROVIDER: S-EPMC7924600 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature