House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins.

ABSTRACT: The establishment of type 2 responses driven by allergic sensitization prior to exposure to helminth parasites has demonstrated how tissue-specific responses can protect against migrating larval stages, but, as a consequence, allow for immune-mediated, parasite/allergy-associated morbidity. In this way, whether helminth cross-reacting allergen-specific antibodies are produced and play a role during the helminth infection, or exacerbate the allergic outcome awaits elucidation. Thus, the main objective of the study was to investigate whether house dust mite (HDM) sensitization triggers allergen-specific antibodies that interact with Ascaris antigens and mediate antibody-dependent deleterious effects on these parasites as well as, to assess the capacity of cross-reactive helminth proteins to

SUBMITTER: Gazzinelli-Guimaraes PH 

PROVIDER: S-EPMC7924806 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature