Viral metagenomics in blood donations with post-donation illness reports from Brazil.

ABSTRACT:

Background

Post-donation illness can be described as appearance of clinical symptoms in blood donors after donation. The consequent call back of the donor to report these symptoms to the blood collection institution is considered a post-donation illness report (PDIR). The most suitable way to examine whether PDIR is related to infection is to apply next-generation sequencing (NGS) and viral metagenomics. Investigation into a PDIR can reveal its importance for transfusion safety and help elaborate strategies for donor education in order to prevent the transfusion transmission of infections which are not routinely tested by the blood collection services.

Materials and methods

We applied NGS and viral metagenomics on blood donations which were deferred due to a PDIR. Thirty-thr

SUBMITTER: Dos Santos Bezerra R 

PROVIDER: S-EPMC7925225 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature