Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia.

ABSTRACT: Preeclampsia is a hypertensive disorder of pregnancy that can involve dangerous neurological symptoms such as spontaneous seizures (eclampsia). Despite being diseases specific to the pregnant state, preeclampsia and eclampsia have long-lasting neurological consequences later in life, including changes in brain structure and cognitive decline at relatively young ages. However, the effects of preeclampsia on brain regions central to memory and cognition, such as the hippocampus, are unclear. Here, we present a case reporting the progressive and permanent cognitive decline in a woman that had eclamptic seizures in the absence of evidence of brain injury on MRI. We then use rat models of normal pregnancy and preeclampsia to investigate mechanisms by which eclampsia-like seizures may disrupt hi

SUBMITTER: Johnson AC 

PROVIDER: S-EPMC7925364 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature