A Novel Experimental Approach for In Vivo Analyses of the Salivary Gland Microvasculature.

ABSTRACT: Microvascular dysfunction plays a fundamental role in the pathogenesis of salivary gland disorders. Restoring and preserving microvascular integrity might therefore represent a promising strategy for the treatment of these pathologies. The mechanisms underlying microvascular dysfunction in salivary glands, however, are still obscure, partly due to the unavailability of adequate in vivo models. Here, we present a novel experimental approach that allows comprehensive in vivo analyses of the salivary gland microvasculature in mice. For this purpose, we employed different microscopy techniques including multi-photon in vivo microscopy to quantitatively analyze interactions of distinct immune cell subsets in the submandibular gland microvasculature required for their infilt

SUBMITTER: Uhl B 

PROVIDER: S-EPMC7925411 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature