Bridging the survival gap in cystic fibrosis: An investigation of lung transplant outcomes in Canada and the United States.

ABSTRACT:

Background

Previous literature in cystic fibrosis (CF) has shown a 10-year survival gap between Canada and the United States (US). We hypothesized that differential access to and survival after lung transplantation may contribute to the observed gap. The objectives of this study were to compare CF transplant outcomes between Canada and the US and estimate the potential contribution of transplantation to the survival gap.

Methods

Data from the Canadian CF Registry and the US Cystic Fibrosis Foundation Patient Registry supplemented with data from United Network for Organ Sharing were used. The probability of surviving after transplantation between 2005 and 2016 was calculated using the Kaplan‒Meier method. Survival by insurance status at the time of transplantation and transpl

SUBMITTER: Stephenson AL 

PROVIDER: S-EPMC7925420 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature