The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.

ABSTRACT:

Purpose

Melanoma is a biologically heterogeneous disease composed of distinct clinicopathologic subtypes that frequently resist treatment. To explore the evolution of treatment resistance and metastasis, we used a combination of temporal and multilesional tumor sampling in conjunction with whole-exome sequencing of 110 tumors collected from 7 patients with cutaneous (n = 3), uveal (n = 2), and acral (n = 2) melanoma subtypes.

Experimental design

Primary tumors, metastases collected longitudinally, and autopsy tissues were interrogated. All but 1 patient died because of melanoma progression.

Results

For each patient, we generated phylogenies and quantified the extent of genetic diversity among tumors, specifically among putative somatic alterations

SUBMITTER: Makohon-Moore AP 

PROVIDER: S-EPMC7925434 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature