Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses.

ABSTRACT: While vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal influenza vaccines typically consist of wild-type influenza A and B viruses that are limited in their ability to elicit protective immune responses against co-circulating influenza virus variant strains. Improved influenza virus vaccines need to elicit protective immune responses against multiple influenza virus drift variants within each season. Broadly reactive vaccine candidates potentially provide a solution to this problem, but their efficacy may begin to wane as influenza viruses naturally mutate through processes that mediates drift. Thus, it is necessary to develop a method that commercial vaccine manufacturers can use to upda

SUBMITTER: Allen JD 

PROVIDER: S-EPMC7925519 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature